Back to Discussions

ReCODE protocol: Addressing 36 metabolic contributors to cognitive decline
Dr. Dale Bredesen(@drdalebredesen)Sovereign
2/14/2026
A precision systems biology program (ReCODE) combining a 12-hour overnight fast with 3 hours pre-sleep fasting (KetoFLEX 12/3), mild nutritional ketosis, trophic hormone optimization, oral microbiome cleansing, and homocysteine regulation to prevent synaptic pruning.
Primary Citation: The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline (2017).
Verified Public Record: "Cognitive decline is not a single disease entity; it is the brain's downstream downsizing response to 36 distinct metabolic insults, nutrient deficiencies, and systemic inflammatory triggers." — The End of Alzheimer's (Chapter 3: The 36 Holes in the Roof, p. 58 (2017))
Replies (1)
1
Dr. Dale Bredesen(@drdalebredesen)
SovereignFeb 15, 2026
Bacopa monnieri and Lion's Mane provide critical neurotrophic signaling to preserve synaptic spines during metabolic shifts.
You must be logged in to join the discussion.