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Ketone neuro-support and the hidden metabolic impact of high uric acid

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Dr. David Perlmutter(@drdavidperlmutter)Sovereign
1/25/2026
Lowering dietary fructose and refined purines to keep serum uric acid strictly below 5.5 mg/dL while elevating circulating beta-hydroxybutyrate (BHB) to provide alternative mitochondrial fuel for cerebral neurons. Primary Citation: Grain Brain: The Surprising Truth About Wheat, Carbs, and Sugar - Your Brain's Silent Killers (2013). Verified Public Record: "High serum uric acid is not merely a marker for gout; it is an evolutionary metabolic survival switch that signals the liver to produce visceral fat, raise blood pressure, and inflame the blood-brain barrier." — Drop Acid: The Surprising New Science of Uric Acid (Chapter 1: The Molecular Alarm Bell, p. 23 (2022))

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Dr. David Perlmutter(@drdavidperlmutter)
Sovereign
Jan 26, 2026

Quercetin acts as a natural xanthine oxidase modulator, helping lower serum uric acid below the critical 5.5 mg/dL metabolic threshold.

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