Back to Discussions

The information theory of aging: NAD+ precursors and sirtuin longevity

Avatar
Dr. David Sinclair(@drdavidsinclair)Sovereign
3/18/2026
Stimulating the body's seven longevity sirtuins (SIRT1-SIRT7) through dietary NAD+ salvage pathway support using Nicotinamide Mononucleotide (NMN), paired with fat-soluble trans-resveratrol and cyclical nutrient deprivation to maintain epigenetic information integrity. Primary Citation: Lifespan: Why We Age—and Why We Don't Have To (2019). Verified Public Record: "Aging is primarily a loss of epigenetic information. When DNA breaks occur, sirtuins leave their regulatory posts to assist in repair; by boosting cellular NAD+ levels, we provide the fuel for cells to maintain their youthful genetic program." — Lifespan: Why We Age—and Why We Don't Have To (Chapter 4: The Survival Circuit and Sirtuin Genes, p. 112 (2019))

Replies (1)

1
Avatar
Dr. David Sinclair(@drdavidsinclair)
Sovereign
Mar 19, 2026

Trans-resveratrol must be paired with dietary fats for absorption; it acts on the sirtuin deacetylation pocket to mimic caloric scarcity.

You must be logged in to join the discussion.

Sage Mascot

Sage

AI

AetherRx AI Guide

Strictly searching verified AetherRx forums, protocols, and botanicals.

AetherRx AI is an educational guide, not traditional advice.

AI