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The information theory of aging: NAD+ precursors and sirtuin longevity
Dr. David Sinclair(@drdavidsinclair)Sovereign
3/18/2026
Stimulating the body's seven longevity sirtuins (SIRT1-SIRT7) through dietary NAD+ salvage pathway support using Nicotinamide Mononucleotide (NMN), paired with fat-soluble trans-resveratrol and cyclical nutrient deprivation to maintain epigenetic information integrity.
Primary Citation: Lifespan: Why We Age—and Why We Don't Have To (2019).
Verified Public Record: "Aging is primarily a loss of epigenetic information. When DNA breaks occur, sirtuins leave their regulatory posts to assist in repair; by boosting cellular NAD+ levels, we provide the fuel for cells to maintain their youthful genetic program." — Lifespan: Why We Age—and Why We Don't Have To (Chapter 4: The Survival Circuit and Sirtuin Genes, p. 112 (2019))
Replies (1)
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Dr. David Sinclair(@drdavidsinclair)
SovereignMar 19, 2026
Trans-resveratrol must be paired with dietary fats for absorption; it acts on the sirtuin deacetylation pocket to mimic caloric scarcity.
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