Dr. Abram Hoffer

Administration of high-dose crystalline nicotinic acid (Vitamin B3: 1,000mg to 3,000mg daily) co-administered with equal amounts of ascorbic acid (Vitamin C) to act as a primary methyl group acceptor and antioxidant buffer, clearing neurotoxic oxidized adrenaline metabolites (adrenochrome) and stabilizing synaptic signaling. Primary Citation: Niacin: The Real Story: Learn about the Wonderful Healing Properties of Niacin (2012). Verified Public Record: "High-dose nicotinic acid acts as a biological acceptor of excess methyl groups, preventing the aberrant accumulation of oxidized adrenaline derivatives like adrenochrome that trigger sensory distortion." — Niacin: The Real Story (Chapter 4: Orthomolecular Psychiatry and Niacin, p. 81 (2012))

Core perspective shared by Dr. Abram Hoffer (International Schizophrenia Foundation, Orthomolecular Medicine News Service): "High-dose flushing nicotinic acid (Vitamin B3) co-administered with ascorbic acid for neuro-metabolic balance" Key Works: Niacin: The Real Story (2012), Orthomolecular Medicine for Everyone (2008).

"Flush-inducing crystalline nicotinic acid (Vitamin B3) paired with ascorbic acid restores NAD+ coenzyme pools and normalizes oxidized catecholamine pathways in the central nervous system."