Dr. David Sinclair
PhD, AO (Genetics, Harvard Medical School Professor) — Paul F. Glenn Center for Biology of Aging Research at Harvard. Focusing on sirtuin activation, nad+ precursors (nmn, nr), resveratrol, information theory of aging. Author of Lifespan: Why We Age—and Why We Don't Have To (2019).
Submitted Protocols
Micronized Trans-Resveratrol for Sirtuin-1 Synaptic Maintenance
Verified Public Record: "Micronized trans-resveratrol dissolved in a lipid matrix acts as an allosteric accelerator of SIRT1 longevity enzymes, supporting cerebral blood flow and epigenetic chromatin stability." — Dr. David Sinclair (Lifespan: Why We Age—and Why We Don't Have To, Chapter 4: The Survival Circuit and Resveratrol Dynamics, p. 134 (2019))
Sirtuin Activation & NAD+ Biosynthesis Protocol
Stimulating the body's seven longevity sirtuins (SIRT1-SIRT7) through dietary NAD+ salvage pathway support using Nicotinamide Mononucleotide (NMN), paired with fat-soluble trans-resveratrol and cyclical nutrient deprivation to maintain epigenetic information integrity.
Dr. David Sinclair: Signature Wellness Protocol
NAD+ biosynthesis support and sirtuin activation via trans-resveratrol, NMN, and intermittent fasting Primary Focus: Sirtuin activation, NAD+ precursors (NMN, NR), resveratrol, information theory of aging. Key Works: Lifespan: Why We Age—and Why We Don't Have To (2019).
Recent Threads
Micronized Trans-Resveratrol for Sirtuin-1 Synaptic Maintenance: Clinical Notes & Guidelines
26d ago"Micronized trans-resveratrol dissolved in a lipid matrix acts as an allosteric accelerator of SIRT1 longevity enzymes, supporting cerebral blood flow and epigenetic chromatin stability." Citation: Lifespan: Why We Age—and Why We Don't Have To — Chapter 4: The Survival Circuit and Resveratrol Dynamics, p. 134 (2019)
The information theory of aging: NAD+ precursors and sirtuin longevity
7mo agoStimulating the body's seven longevity sirtuins (SIRT1-SIRT7) through dietary NAD+ salvage pathway support using Nicotinamide Mononucleotide (NMN), paired with fat-soluble trans-resveratrol and cyclical nutrient deprivation to maintain epigenetic information integrity. Primary Citation: Lifespan: Why We Age—and Why We Don't Have To (2019). Verified Public Record: "Aging is primarily a loss of epigenetic information. When DNA breaks occur, sirtuins leave their regulatory posts to assist in repair; by boosting cellular NAD+ levels, we provide the fuel for cells to maintain their youthful genetic program." — Lifespan: Why We Age—and Why We Don't Have To (Chapter 4: The Survival Circuit and Sirtuin Genes, p. 112 (2019))
Dr. David Sinclair on Sirtuin activation
11mo agoCore perspective shared by Dr. David Sinclair (Paul F. Glenn Center for Biology of Aging Research at Harvard): "NAD+ biosynthesis support and sirtuin activation via trans-resveratrol, NMN, and intermittent fasting" Key Works: Lifespan: Why We Age—and Why We Don't Have To (2019).
Recent Comments
""Micronized trans-resveratrol dissolved in a lipid matrix acts as an allosteric accelerator of SIRT1 longevity enzymes, supporting cerebral blood flow and epigenetic chromatin stability." — Verified Citation: Lifespan: Why We Age—and Why We Don't Have To (Chapter 4: The Survival Circuit and Resveratrol Dynamics, p. 134 (2019))"
"Trans-resveratrol must be paired with dietary fats for absorption; it acts on the sirtuin deacetylation pocket to mimic caloric scarcity."
